In a new comment on Madonna’s new TikTok video, 50 Cent begins yet another back-and-forth with the Queen of Pop, Madonna.

The two have been notable for their fiery exchanges over the past few years.

According to Page Six, it was 50 Cent who rekindled the feud.

Specifically, the rapper has recently aimed at Madonna’s seductive Instagram photos and a couple of disturbing TikTok posts that were reposted on the former platform.

50 Cent posted a screenshot of Madonna in an unflattering angle on her new video with a rather personal headline on one of his posts:

“Madonna Using Rap Music for Clout On TikTok Is Pathetic And Truly Disturbs My Spirit.”

The video in question was Madonna’s latest TikTok, in which she was jamming to Lil Keem’s “Vent,” mouthing the lyrics effortlessly while headbanging with a braid. Cent posted:

“told y’all grand ma was on bullshit! like a virgin at 64. LOL #bransoncognac #lecheminduroi.”

Meanwhile, fans have echoed Cent’s remarks, pointing out Madonna’s unpredictable behavior.

A user posted:

“Her face looks like a transplant of fresh baby skin.”

Another asked:

“What happened to her face whole legacy down the drain.”

Madonna has yet to respond to 50 Cent’s comments as of this writing.

However, not all comments on 50 Cent’s post were negative; some defended Madonna in her honor and called out the rapper in return.

Someone pointed out:

“Y’all forgetting that y’all too, someday will all get Wrinkly and Older…… She’s an iconic figure and still doing her thing. 50Cent, You’re in your 50’s…. You’re not behind her.”

A Madonna fan said:

“Now come on 50, I know you’re old enough to remember what an icon she was. She was always in it for the shock factor, she was one of the creators and paved the way for artist to be who there are. She’s always been inclusive despite race, age, sexuality, etc. she hasn’t changed.”

50 Cent had previously compared Madonna’s face to an alien earlier this year. They had a long-standing love-hate relationship.

Madonna delivered the perfect clap back last year, slamming the rapper for his phony friendship.

She said in an Instagram story:

“Here is 50 Cent pretending to be my friend. Now you have decided to talk smack about me. I guess your new career is getting attention by trying to humiliate others on social media. The least elevated choice you could make as an artist and an adult.”